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      史衛峰教授在《自然綜述-微生物學》發文論述寨卡病毒毒力與基因組進化研究


      2019年01月10日 14:26 點擊:[]

      1月7日,我校史衛峰教授在《自然綜述-微生物學》(NATURE REVIEWS MICROBIOLOGY)上發表文章,對近年來寨卡病毒相關研究進展進行了綜述。

      寨卡病毒(Zika virus)與登革病毒、黃熱病毒等同為黃病毒科黃病毒屬成員,該病毒最早于1947年分離于烏干達Zika森林,并因此得名。自2007年在密克羅尼西亞造成疫情后,寨卡病毒逐漸在太平洋諸島嶼中傳播,最終登陸美洲大陸,造成了2015-2016年的寨卡病毒大流行。在此過程中,寨卡病毒與其它黃病毒差異較大的致病與傳播特征逐漸被發現。寨卡病毒對孕期女性的感染可導致胎兒的流產或新生兒小頭癥,對公共衛生和人口健康構成了嚴重威脅。研究表明,寨卡病毒pr蛋白中的S139N變異使其致小顱畸形的能力顯著增強。而NS1蛋白中的A982V突變增強了寨卡病毒從哺乳動物模型到蚊蟲媒介的傳播能力,還可增強病毒對IFN-β產生的抑制,因此可能與寨卡病毒對人類的感染有關。

      本文詳述了寨卡病毒基因組139、982以及2634等重要位點的遺傳變異規律,通過比較這些位點的氨基酸多態性,將寨卡病毒亞洲家系劃分成不同基因型,并且重溯了不同型別寨卡病毒在亞太及美洲地區傳播的路線及關鍵時間節點,認為東南亞寨卡病毒遺傳樣性較高。文章建議加強東南亞蚊蟲中寨卡病毒的檢測和監測,這對亞太地區甚至全球寨卡疫情的預防和控制具有重要意義。

      該文還總結了可能影響寨卡病毒流行與致病特征的其它遺傳位點,以及可能的非病毒學因素,如全球運輸與交流的增多、人口增長與城市化,氣候變化導致蚊蟲媒介分布范圍擴大等等。文章指出,未來研究中進一步結合反向遺傳學技術與新型動物模型的重要意義,以及在熱帶、亞熱帶建立嚴密的蚊媒病毒監控網絡的關鍵作用。該文對未來黃病毒的防治與研究均有著重要的借鑒意義。

      NATURE REVIEWS MICROBIOLOGY為生物類TOP期刊,2017年的影響因子為31.851。中山大學醫學院劉忠鈺副教授為本文第一作者,泰山醫學院史衛峰教授、軍事科學院軍事醫學研究院秦成峰研究員為本文通訊作者。研究工作得到了國家重點研發計劃、國家優秀青年基金、英國醫學科學院/國家自然科學基金牛頓高級學者基金、山東省泰山學者工程等項目的支持。

      文章鏈接:https://www.nature.com/articles/s41579-018-0134-9#article-info

       

      (供稿:科研處 通訊員:李曉梅 編輯:王承柱)

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